Glutathione-Induced Conversion of Pentavalent Antimony to Trivalent Antimony in Meglumine Antimoniate
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چکیده
منابع مشابه
Glutathione-induced conversion of pentavalent antimony to trivalent antimony in meglumine antimoniate.
The standard treatment of human leishmaniases involves the use of pentavalent antimony [Sb(V)] compounds, including meglumine antimoniate. The mode of action of these compounds has not been fully elucidated. The possibility that Sb(III) is involved has been suggested; however, the biomolecule that may induce the conversion of Sb(V) to Sb(III) has not yet been identified. In the present study, w...
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The pentavalent antimonies, mainly the meglumine antimoniate, are recommends as first-choice medicines for leishmaniasis therapy. In this work we described the development of formulations of meglumine antimoniate injectable medication, as well as the analytical methodology used in the selective determination of Sb(III) and Sb(Total) by hydride generation - inductively coupled plasma atomic emis...
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Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tissues after SbV administration. In thi...
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Pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate, have been used for more than half a century in the therapy of the parasitic disease leishmaniasis. Even though antimonials are still the first-line drugs, they exhibit several limitations, including severe side effects, the need for daily parenteral administration and drug resistance. The molecular structure of ...
متن کاملComparisso of intralesionally injected Zink sulfate and pentavalent Antimony compound in treatment of acute cutaneous leishmaniasis
acute cutaneous leishmaniasis(ACL) is an endemic disease in developing countries.the first line drug for treatment of ACL.according to WHO recommendation,is the pentavalent antimony compounds such as meglumine antimoniate(Glucantime{SB}).high cost ,side effects,multiple injections and incomplete efficacy are limitations of this therapy.we evaluated the efficacy of intralesional(IL) injection of...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2001
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.45.3.913-916.2001